The theme for our 8th journal club will be on Antibiotic prophylaxis in colorectal surgery – SSIs / Bowel Prep

Manuscripts to be discussed: 

RCTs:

Koskenvuo et al. Sep 2019. LANCET.  Mechanical and oral antibiotic bowel preparation versus no bowel preparation for elective colectomy (MOBILE): a multicentre, randomised, parallel, single-blinded trial

Eloy Espin et al. Aug 2020. LANCET. Preoperative oral antibiotics and surgical-site infections in colon surgery (ORALEV): a multicentre, single-blind, pragmatic, randomised controlled trial

as well as a systematic review / meta-analysis on the TOPIC:

Nelson et al. 2020 Antibiotic prophylaxis in colorectal surgery: are oral, intravenous or both best and is mechanical bowel preparation necessary?

With brief look at what the latest NICE Guidelines say specifically on the topic:

NICE Guideline on SSI prevention and treatment: NG125 updated Aug 2020 (https://www.nice.org.uk/guidance/ng125/resources/2019-exceptional-surveillance-of-surgical-site-infections-prevention-and-treatment-nice-guideline-ng125-6727243069/chapter/Surveillance-decision?tab=evidence)